|
See also:
My name is Bryan Alan Krumm. I am 36 years old. I am a registered
nurse at the University of New Mexico Mental Health Center and I am
working with New Mexicans for Compassionate Use to end the damage caused
to our society by the "war on drugs". I am recognized by the New Mexico
court system as an expert on the medical uses of marijuana and the
history of medical marijuana. I have been studying the history, effects,
and uses of marijuana for over 15 years. I am the chief researcher for
the Cannabis Research Library, the largest online collection of cannabis
research in the world
I use marijuana for the treatment of depression and knee pain,
and my primary care physician has refered me to the Lynn Pierson
Therapeutic Research Program. This program was established under
the Controlled Substances Therapeutic Research Act in 1978, and allows
the medical use of marijuana in New Mexico. Under this program,
research was conducted which proved the safety and efficacy of smoked
marijuana for the treatment of multiple sclerosis and for treating the
nausea and vomiting associated with cancer chemotherapy. Unfortunately,
the unreasonable, arbitrary and capricious actions of the US government
led to closure of the program when they refused to approve further
research protocols and then cut off our supply of marijuana entirely.
Therefore, I have three choices. I can to turn to an unreliable and
dangerous "black market". I can risk losing everything I have by
cultivating my own medicine. Or, I can go without a needed medication
that has unique pharmacological properties which can not be mimicked by
any other known class of drug.
The human body contains a complex system of cannabinoid receptors
and produces its own cannabinoids (1,2,3,4), forming an endogenous
cannabinod system that is involved in normal homeostasis of the immune
system (5,6,7,8), transmission of pain responses (9,10.11,12,13),
perception, and mood (1,8). It has been shown that dysfunction of the
endogenous cannabinoid system is involved in certain disease states
(14,15,16,17,18). It has also been shown that the use of cannabinoids,
such as those found in marijuana, may be effective in treating many of
those diseases (15,19,20,21,22,23). It has been shown that different
cannabinoids act synergistically to produce greater therapeutic effect
than single cannabinoid therapy. When the CB1 receptor agonist
anandamide is given at the same time as the CB2 receptor agonist
palmitoylethanolamide, they produce an analgesic effect one hundred
times greater than either substance when administered by itself (22).
The reason for this synergistic effect is that the human body
contains different types of cannabinoid receptors which react
differently to different cannabinoids, and are involved in different
aspects of the disease process. For instance, THC is available legally
in the United States as a Schedule III drug. THC is a strong CB1
receptor agonist but has minimal activity at the CB2 receptor and may
actually act as an antagonist at the CB2 receptor (14). CB2
receptor agonists may prove to be an important class of medications
for the treament of autoimmune diseases (7) and are found in whole
marijuana but not in THC capsules.
Cannabinoids have been shown to protect the brain against damage
from stroke and trauma (23,24,25) and may protect against age related
neurodegenerative disorders such as alzheimers.(25). Cannabinoids
may also protect against certain types of cancer (26) and have been
shown shown to inhibit proliferation of certain types of tumor cells
(27,28,29) and reduce tumor size. (28)
Although the federal government is aware of the therapeutic
potential of marijuana, they have routinely suppressed scientific
findings. For example, a two year study of THC was conducted on rats
and mice that found THC treated animals had significantly lower rates
of many types of cancer. This report was shelved for over two years
until a copy was leaked to AIDS Treatment News, stamped on every page
"NOT FOR DISTRIBUTION OR ATTRIBUTION" (30). Health and Human Services
quickly made a version available to the public after being being
confronted with the leaked copy (26).
Another example is the 1997 NIH Workshop on the Medical Utility
of Marijuana. The transcripts from the workshop show that the panel
of experts agreed marijuana has medical value (31). It was even found
that "the evidence is perfectly clear that smoking is an outstanding
route of administration....it's a very safe drug and therefore it would be
perfectly safe medically to let the patient determine their own dose
through the smoking route" (ibid p.28-29). The Executive Summary that
was issued to the public by NIH was far less enthusiastic than the
group of experts. It recommended further research and no smoking (32).
This comes as little surprise. For over a century, every serious
scientific inquiry into the effects of marijuana have found it to be an
incredibly safe drug that causes little harm to society. It has
routinely been found that marijuana prohibition causes more harm to
society than marijuana use (33). The US Government has routinely
ignored science, as well as the will of The People, who have passed
medical marijuana measures. They continue to persecute all marijuana
users, including those who need its important healing properties.
After all, marijuana prohibition is founded in racism and intolerance,
not science.
When the Mexican American War was ended by the Treaty of Guadalupe
Hidalgo, it did not end the hostile feelings many Americans harbored
towards Mexicans. As Mexicans immigrated to the western states and took
scarce jobs, it created more tension. These immigrants also brought
their cultural and religious traditions, one of which was the use of
"marijuana" for medical, religious, and recreational purposes.
Within the traditions of Curanderismo, marijuana is called La Santa
Rosa, or the sacred rose. It is used as part of a religious healing
ceremony and is considered to be a piece of the heart of God (34,35).
When passing its first anti-marijuana laws in 1929, the Montana
Legislature, described such a ceremony as an "imaginary bullfight for
the favor of Spanish Rose" and went on to say it deplores these
"international complications" (36).
Numerous state legislatures described marijuana as a drug that
causes Mexicans to go insane when passing early marijuana laws. The
attitudes and intent of the people of Colorado are illustrated in a
letter from Floyd K. Baskette, City Editor of The Alamosa Daily
Courier of Alamosa, Colorado, which was read into the record of the
hearings on the 1937 Marihuana Tax Act (the first federal law
regulating marijuana) by Harry J. Anslinger, Commissioner of the
Federal Bureau of Narcotics. This letter stated in part:
While this was considered in passing federal anti-marijuana
legislation, the opinion of the American Medical Association was
ignored. Dr. William C. Woodward was Chief Counsel to the American
Medical Association. The AMA was aware of the therapeutic potential
of marijuana (or as they knew it, cannabis) and did not want it to be
removed from medical use. Dr. Woodward came to testify for the AMA
testifying that, "The American Medical Association knows of no evidence
that marihuana is a dangerous drug." One of the Congressmen said in
response, "Doctor, if you can't say something good about what we are
trying to do, why don't you go home?" The next Congressman said,
"Doctor, if you haven't got something better to say than that, we are
sick of hearing you." (38)
Early marijuana laws were intended not only to oppress Mexican
immigrants but to prevent them from the free practice of religion.
Today these laws not only prevent millions of Americans from freely
practicing religion but millions more suffer from lack of needed
medication under these oppressive policies. Millions of others have
suffered the severe legal and social consequences associated with
being arrested for marijuana use. There is no scientific rationale
to justify the criminalization and persecution of millions of
otherwise law abiding citizens.
Prohibition serves to protect the financial interests of
industries that would have to compete with marijuana in a free market.
It assures the financial success of those who responsible for waging
this war on the American People. It strips us of our inalienable
rights to life, liberty, and the pursuit of happiness. I live in
fear that a small army of masked gunmen may come bursting through my
door at 3 am and shoot me in the back while I'm lying in bed, simply
for being a medical marijuana user. In view of the number deaths by
drug warrior we suffer from, it's a very real fear for medical
marijuana patients living in the United States.
REFERENCES
1. Howlett AC. Pharmacology of cannabinoid receptors. Annu Rev Pharmacol
Toxicol. 1995;35:607-634.
2. Abood ME and Martin BR. Molecular neurobiology of the cannabinoid
receptor. Intl Rev Neurobiol. 1996;39:197-221.
3. Devane WA, Hanus L, Breur A, et al. Isolation and structure of a brain
constituent that binds to the cannabinoid receptor. Science.
1992;258:1946-1949.
4. Barg J, Fride E, Hanus L, et al. Cannabinomimetic behavioral effects
of and adenylate cyclase inhibition by two new endogenous anandamides.
Eur J Pharmacol. 1995;287:145-152.
5. Klein TW, Newton C and Friedman H. Cannabinoid receptors and
immunity. Immunol Today. 1998; 797:225-233.
6. Daaka Y, Friedman H and Klein TW. Cannabinoid receptor proteins
are increased in jurkat, human T-cell line after mitogen activation.
J Pharmacol Exp Ther. 1996;276:776-783.
7. Kaminski, NE; Immune regulation by cannabinoid compounds through
the inhibition of the cyclic AMP signaling cascade and altered gene
expression. Biochem Pharmacol 1996; 52(8):1133-40,
8. Di Marzo V. 'Endocannabinoids' and other fatty acid derivatives
with cannabimimetic properties: biochemistry and possible
physiopathological relevance. Biochimica et Biophysica Acta.
1998;1392(2-3):153-75.
9. Smith PB, Compton DR, Welch SP, et al. The pharmacological
activity of anandamide, a putative endogenous cannabinoid in mice.
J Pharmacol Exp Ther. 1994;270:219-227.
10. Martin WJ, Hohmann AG and Walker JM. Suppression of noxious
stimulus-evoked activity of the thalamus by a cannabinoid agonist:
correlation between electrophysiological and antinociceptive effects.
J Neurosci. 1996;16:6601-6611.
11. Meng ID, Manning BH, Martin WJ and Fields HL. An analgesia
circuit activated by cannabinoids. Nature. 1998;395:381-383.
12. Walker, MJ; Huang, SM, Strangman, NM; Tsou, K; and
Sañudo-Peña MC; Pain modulation by release of the endogenous cannabinoid
anandamide (analgesia / periaqueductal gray / microdialysis / gas
chromatography / mass spectrometry) PNAS; 1999; 96: 12198-12203,
13. Herzberg U, Eliav E, Bennett GJ and Kopin IJ. The analgesic effects
of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a
rat model of neuropathic pain. Neurosci Let. 1997;221:157-160.
14. Felder, CC & Glass, M; Cannabinoid Receptors and Their Endogenous
Agonists. Annu. Rev. Pharmacol. Toxicol. 1998. 38:179-200.
15. Molina-Holgado, F; Molina-Holgado, E; Guaza, C; The endogenous
cannabinoid anandamide potentiates interleukin-6 production by
astrocytes infected with Theiler's murine encephalomyelitis virus by a
receptor-mediated pathway. Feb Lett; 433: 139-142.
16. Emrich, HM; Leweke, FM; Schneider, U; Towards a cannabinoid
hypothesis of schizophrenia: cognitive impairments due to dysregulation
of the endogenous cannabinoid system. Pharmacology, Biochemistry &
Behavior.; 1997; 56:803-7.
17. Richardson JD; Aanonsen L; Hargreaves KM; Hypoactivity of the
spinal cannabinoid system results in NMDA-dependent hyperalgesia. J
Neurosci 1998, 18:451-7.
18. Sanudo-Pena MC; Walker JM; Role of the subthalamic nucleus in
cannabinoid actions in the substantia nigra of the rat. J Neurophysiol,
1997, 77:1635-8.
19. Smith PB, Compton DR, Welch SP, et al. The pharmacological activity
of anandamide, a putative endogenous cannabinoid in mice. J Pharmacol
Exp Ther. 1994;270:219-227.
20. Gallily, R; Yamin, A; Waksmann, Y; Ovadia, H; Weidenfeld, J;
Bar-Joseph, A; Biegon, A.; Mechoulam, R; and Shohami, E; Protection
Against Septic Shock and Suppression of Tumor Necrosis Factor and
Nitric Oxide Production by Dexanabinol (HU-211), a Nonpsychotropic
Cannabinoid. J Pharm Exp Ther, 1997; 283: 918-924, 1997.
21. Lyman WD, Sonett JR, Brosnan CF, et al. ?9-tetrahydrocannabinol:
a novel treatment for experimental autoimmune encephalomyelitis. J
Neuroimmunol. 1989;23:73-81.
22. Calignano A, La Rana G, Giuffrida A and Piomelli D. Control of pain
initiation by endogenous cannabinoids. Nature. 1998;394:277-281.
23. Hampson, A; Grimaldi, M; Axelrod, J; and Wink, K; Cannabidiol and
(delta)9-tetrahydrocannabinol are neuroprotective antioxidants. PNAS 1998 95:
8268-8273.
24. Nagayama, T; Sinor, AD; Simon, RP; Chen, J; Graham,SH; Jin, K; and
Greenberg, DA; Cannabinoids and Neuroprotection in Global and Focal
Cerebral Ischemia and in Neuronal Cultures. J Neurosci; 1999,
19:2987-2995
25. Shen M; Thayer SA; Cannabinoid receptor agonists protect cultured
rat hippocampal neurons from excitotoxicity. Mol Pharmacol, 1998;
54:459-62.
26. NTP Technical Report on the Toxicology and Carcinogenesis Studies
of 1-Trans-Delta(9)-Tetrahydrocannabinol (CAS No. 1972-08-3) in F344/N
Rats and B6C3F(1) Mice (Gavage Studies); NTP TR 446, NIH Publication
No. 94-3362, of the U.S. Department of Health and Human Services, Nov.
1996
27. De Petrocellis L; Melck D; Palmisano A; Bisogno T; Laezza C; Bifulco
M; Di
Marzo V; The endogenous cannabinoid anandamide inhibits human breast cancer
cell proliferation. Proc Nat'l Acad Sci, 1998; 95:8375-80.
28. Munson AE, Harris LS, Friedman MA, Dewey WL, Carchman RA, Antineoplastic
activity of cannabinoids. J Nat'l Cancer Inst, 1975; 55:597-602.
29.Sánchez,C; Galve-Roperh, I; Canova, C; Brachet, P; Guzmán M; Delta
9-Tetrahydrocannabinol induces apoptosis in C6 glioma cells. Feb Lett, 1998;
436: 6-10.
30.James, J.S.; Medical Marijuana: Unpublished Federal Study Found THC-
Treated
Rats Lived Longer, Had Less Cancer, AIDS Treatment News 263,1997
31. National Institutes of Health. Transcript of the NIH Workshop on the
Medical Utility of Marijuana. Tab B, Deliberations of the Ad Hoc Group of
Experts; February 19&20, 1997. (Ace-Federal Reporters, Inc., Cr66002.0) Ref
Type: Transcript, p.21-33
32. Executive Summary of the Workshop on the Medical Utility of Marijuana;
National Institutes of Health; February 19&20, 1997.
34. Partridge WL. Cannabis and cultural groups in a Colombian municipo, In:
Rubin V, ed., Cannabis and Culture, (1973) pages 147-172 (Mouton Publishers,
Paris).
35. Furst, PT; Flesh of the Gods, the Ritual Use of Hallucinogens (1972)
(Waveland Press Inc, Prospect Heights)
36. Richard J. Bonnie and Charles H. Whitebread, II; The Forbidden Fruit
and the Tree of Knowledge: An Inquiry into the Legal History of American
Marijuana Prohibition. Virginia Law Review 971-1203 (1970).
37. The Marihuana Tax Act of 1937, Transcripts of Congressional Hearings,
Additional Statement of H. J. Anslinger, Commissioner of Narcotics
(last modified April 6, 1997)
38. Charles H. Whitebread, II, The History of the Non-Medical Use of
Drugs in the United States (last modified April 6, 1997)
See also: |
|